Author

Ness Little

University of TorontoORCID 0009-0006-4998-1411Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Judy YaniD· 2 shared Narisa Dhupar· 2 shared Stephan Ong ToneiD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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2 shared papersCell Biology

Judy YanORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintSep 3, 2026

Adeno-Associated Virus Mediated Expression of Bcl-xL Attenuates Apoptosis in Fuchs Endothelial Corneal Dystrophy

Ness Little, Judy Yan, Narisa Dhupar, Stephan Ong Tone

This study evaluates AAV-mediated Bcl-xL expression in FECD to reduce apoptosis, finding significant protection in FECD CECs.

DOI 10.64898/2026.09.01.748650

humanexperimental assay

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Cell BiologybioRxivPreprintSep 1, 2026

Differential expression of NEAT1 in the corneal endothelium increases susceptibility to oxidative stress in Fuchs Endothelial Corneal Dystrophy

Narisa Dhupar, Judy Yan, Ness Little, Stephan Ong Tone

This study identifies reduced NEAT1 expression in the central corneal endothelium as a factor increasing susceptibility to oxidative stress in Fuchs Endothelial Corneal Dystrophy.

DOI 10.64898/2026.08.31.748332

humanbulk RNA-seq

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