Xiaowei Dong

This study introduces pseudo-haplotype analysis to characterize multi-variant configurations in BAF chromatin remodeling genes, revealing common and rare variant co-occurrence patterns across populations.

This study develops a helicase-specific variant effect predictor to classify SMARCA4 variants as damaging or tolerated, improving interpretation of genetic variants of uncertain significance.

The paper identifies ARID1B variants that impair protein interactions, stability, and regulation, linking them to neurodevelopmental disorders and cancers.

The paper analyzes BAF complex gene co-expression across human tissues to identify tissue-specific regulatory patterns and their functional implications.

This study identifies 5hmC-based gene set activity scores in cfDNA as biomarkers for early detection of ADT resistance in prostate cancer.