Molecular BiologybioRxivPreprint
Developmental regulators drive DUX4 expression in facioscapulohumeral muscular dystrophy
Amelia Fox, Jonathan Oliva, Rajanikanth Vangipurapu, Francis M. Sverdrup
This study identifies SIX transcription factors as key regulators of DUX4 expression in FSHD muscle cells, showing they drive DUX4 transcription and are negatively regulated by DUX4 itself.
DOI 10.1101/2024.05.21.595131