Author

Yichen Chu

Chinese University of Hong Kong, ShenzhenORCID 0009-0006-7367-9685Unclaimed ORCID profile · follow to get notified of new preprints

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Cancer Biology· 1

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Approach:statistical model· 1

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Xuanming ZhangiD· 1 shared Zicheng WangiD· 1 shared 盛小夏 Sheng Xiaoxia· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperCancer Biology

Xuanming ZhangORCID

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Cancer BiologybioRxivPreprintSep 28, 2026

Mutation Order and Selection Shape Intratumor Heterogeneity in Tumor Evolution

Yichen Chu, 盛小夏 Sheng Xiaoxia, Xuanming Zhang, Zicheng Wang

This study develops a branching-process model to show how mutation order and selection shape intratumor heterogeneity by analyzing pathway-specific clone dynamics and fitness effects.

DOI 10.64898/2026.09.24.754285

statistical model