NIAGADS provides a national data repository for Alzheimer's Disease and related dementia genetics and genomics research, hosting genome and exome sequence data from over 209,000 samples.

10 citations

humanwhole-genome sequencing

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NeuroscienceNature CommunicationsPeer-reviewedSep 9, 2024

Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes

Kurt W. Farrell, Jack Humphrey, Timothy S. Chang…·Adam Naj

This study identifies six genetic loci associated with progressive supranuclear palsy, including a novel locus, and links them to oligodendrocytic dysfunction and C4A expression.

54 citationstop 1%

humanGWAS summary statistics

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GeneticseLifePeer-reviewedDec 12, 2023

Biobank-wide association scan identifies risk factors for late-onset Alzheimer's disease and endophenotypes

Donghui Yan, Bowen Hu, Burcu F. Darst…·Qiongshi Lu

The paper uses BADGERS to identify risk factors and endophenotypes for late-onset Alzheimer's disease by analyzing biobank-wide data.

10 citations

humanGWAS summary statistics

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Genetic & Genomic MedicinemedRxivPreprintJul 6, 2023

Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK, GRB14, and KIAA0825 as novel risk loci for Alzheimer disease: the Alzheimer Disease Genetics Consortium

Farid Rajabli, Penelope H. Benchek, Giuseppe Tosto…·Matthew P. Frosch

This study identifies novel Alzheimer's disease risk loci by analyzing multi-ancestry GWAS data from diverse populations, highlighting the importance of including underrepresented groups in genetic research.

11 citations

humanGWAS summary statistics

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Genetic & Genomic MedicineJournal of Alzheimer s DiseasePeer-reviewedJan 18, 2022

Alzheimer's disease variant portal (ADVP): a catalog of genetic findings for Alzheimer's disease

Pavel P. Kuksa, Chia‐Lun Liu, Wei Fu…·Yuk Yee Leung

The paper introduces ADVP, a catalog of Alzheimer's disease genetic associations, integrating data from over 200 GWAS publications to provide harmonized and searchable genetic findings.

24 citationstop 4%

humanGWAS summary statistics

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Genetic & Genomic MedicinemedRxivPreprintMar 14, 2021

Genome-Wide Meta-Analysis of Late-Onset Alzheimer's Disease Using Rare Variant Imputation in 324,809 Subjects Identifies Novel Rare Variant Locus NCK2: The International Genomics of Alzheimer's Project (IGAP)

Adam Christian Naj, Ganna Leonenko, Xueqiu Jian…·Gerard D. Schellenberg

18 citations

humanwhole-genome sequencing

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BioinformaticsJournal of Alzheimer s DiseasePeer-reviewedSep 24, 2019

Inferring the molecular mechanisms of noncoding Alzheimer’s disease-associated genetic variants

Alexandre Amlie‐Wolf, Mitchell Tang, Jessica Way…·Gerard D. Schellenberg

The paper identifies enhancer dysregulation and target genes for noncoding Alzheimer's disease-associated variants using GWAS and eQTL data.

31 citations

humanGWAS summary statistics

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GeneticsNature GeneticsPeer-reviewedFeb 25, 2019

A statistical framework for cross-tissue transcriptome-wide association analysis

Yiming Hu, Mo Li, Qiongshi Lu…·Hongyu Zhao

The paper introduces a statistical framework for cross-tissue transcriptome-wide association analysis, improving gene-trait association detection and identifying novel genes related to late-onset Alzheimer's disease.

415 citationstop 1%

humanbulk RNA-seq

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