Burcu F. Darst

The paper identifies 43 genetic loci that modify the effect of fish oil supplementation on dementia risk using UK Biobank data.

Admix-kit provides tools for genetic analysis of admixed populations, enabling simulation, association testing, and polygenic scoring.

The paper uses BADGERS to identify risk factors and endophenotypes for late-onset Alzheimer's disease by analyzing biobank-wide data.

This study identifies 447 new genetic variants associated with prostate-specific antigen levels across multiple ancestries and shows improved cross-ancestry prediction of PSA, with implications for personalized prostate cancer screening.

The paper demonstrates that TOPMed imputation improves the identification of rare variants associated with type 2 diabetes in Latino populations, leading to novel associations and better polygenic scores.

The paper quantifies similarity in causal effects across local ancestries in admixed individuals and finds high genetic correlation (radmix=0.95) within individuals.

The paper performs a metabolome-wide association study to identify CSF metabolite-phenotype associations in neurological and psychiatric disorders.

The paper identifies seven metabolites associated with executive function decline in early Alzheimer’s disease using longitudinal plasma samples from the WRAP cohort.

The paper identifies CSF metabolites associated with tau levels and shows they improve prediction of Alzheimer's disease status.

The paper integrates genomics, metabolomics, and Alzheimer’s risk factors from 1,111 participants to identify gene-metabolite-AD risk factor relationships and metabolites explaining tau variance.

This study identifies age and sex-associated metabolite trajectories in longitudinal plasma samples from the WRAP cohort, revealing sex-specific changes in metabolites like sphingolipids and heritability patterns.