GenomicsProceedings of the National Academy of SciencesPeer-reviewed
Predicting the unseen: a diffusion-based debiasing framework for transcriptional response prediction at single-cell resolution
Ergan Shang, Yuting Wei, Kathryn Roeder
This paper introduces dbDiffusion, a diffusion-based framework for predicting transcriptional responses to unmeasured genetic perturbations using Perturb-seq data, achieving better accuracy than existing methods.
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