Author

Aaron Jaech

OpenAI (United States)ORCID 0009-0007-1530-2027Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:human· 1 Approach:large language model· 1 Approach:machine learning (classical)· 1 Assay:proteomics· 1

Frequent Co-Authors

Aaron BodanskyiD· 1 shared Bas van OpheusdeniD· 1 shared Bernard KhoriD· 1 shared James ZouiD· 1 shared Joseph L. DeRisiiD· 1 shared Kenny Kim· 1 shared Kyle SwansoniD· 1 shared Monica T. DayaoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 18 mutual co-author links

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1 shared paperBioinformatics

Aaron BodanskyORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintApr 16, 2026

ORION: An agentic reasoning construct for the analysis of complex human immune profiling

Monica T. Dayao, Kenny Kim, Bernard Khor…·Joseph L. DeRisi

ORION uses AI to analyze immune profiling data, reducing analysis time from months to hours and generating testable hypotheses.

DOI 10.64898/2026.04.13.718286

humanproteomics

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BioinformaticsbioRxivPreprintMay 19, 2025

RL-Finetuning of OpenAI o1-mini to Enhance Biomedical Reasoning

Kyle Swanson, Yiqun T. Chen, Aaron Jaech, James Zou

This study evaluates the effectiveness of RL finetuning o1-mini for biomedical reasoning tasks and finds mixed results in gene classification and small molecule prediction.

DOI 10.1101/2025.05.19.654988

machine learning (classical)benchmarking

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