Jared Strauch

Tissue-aware elastic net decomposition reveals shared and lineage-specific drug response biomarkers

The paper introduces DSEN, a tissue-aware regression method that improves drug response prediction by decomposing models into shared and lineage-specific components, achieving better performance and interpretability.

Widespread data leakage inflates accuracy and corrupts biomarker discovery in cancer drug response prediction

The paper shows that data leakage in drug response prediction models inflates accuracy and corrupts biomarker discovery, and provides a solution to avoid this issue.

Improving Drug Sensitivity Prediction and Inference by Multitask Learning

This paper improves drug sensitivity prediction using multitask learning, showing better accuracy for sensitive cell lines and identifying tissue-specific predictors.