Author

Zhenjia Gan

New York University ShanghaiORCID 0009-0007-3572-6484Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Guangyong CheniD· 1 shared Jiabin Yin· 1 shared John Z. H. ZhangiD· 1 shared Junde Xu· 1 shared Juping Huang· 1 shared Yuzhi XuiD· 1 shared Zhihao Wu· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Guangyong ChenORCID

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1 paper

Recent·Most cited

BiochemistryJournal of the American Chemical SocietyPeer-reviewedSep 4, 2026

CatESO: Differentiable Enzyme Sequence Optimization Guided by Substrate-Aware kcat Prediction

Zhenjia Gan, Yuzhi Xu, Junde Xu…·John Z. H. Zhang

CatESO optimizes enzyme sequences to improve catalytic turnover by integrating kcat prediction with differentiable design, achieving higher predicted activity and structural confidence than existing methods.

DOI 10.1021/jacs.6c14365

protein sequencedeep learning

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