Qirui Zhang

The paper shows that transcriptional perturbations have structured effects beyond a global trend, with specific patterns transferable across datasets.

SCADS integrates GWAS data with scATAC-seq to identify disease-relevant cell states and regulatory programs, showing heterogeneity in immune cell types for inflammatory bowel disease.

DiffDriver identifies context-specific selection of cancer driver genes by accounting for mutation rate variations and functional sequence information, revealing differential selection in clinical traits and immune subtypes.