GeneticsProceedings of the National Academy of SciencesPeer-reviewed
Evidence for strong purifying selection of human 47S ribosomal RNA genes
Xufan Ma, Fiona Chow, Woodward B. Galbraith…·Andreas Hochwagen
The paper analyzes sequence variants in human 47S rRNA genes across 3,000 individuals to show strong purifying selection against deleterious variants, suggesting potential disease associations that have been overlooked.