Andreas Hochwagen

The paper shows that multiple mechanisms suppress meiotic recombination near chromosome ends in yeast, involving both axis protein downregulation and DNA break suppression.

The paper identifies a distinct mode of meiotic chromosome synapsis that occurs independently of homology and is regulated by ATR/Mec1 and Zip1 phosphorylation.

The paper identifies a conserved protein interaction between axis core proteins and cohesin complexes in fungi and plants, revealing a mechanism for meiotic chromosome architecture.

The paper analyzes sequence variants in human 47S rRNA genes across 3,000 individuals to show strong purifying selection against deleterious variants, suggesting potential disease associations that have been overlooked.

The paper investigates Spo11 dimerization in S. cerevisiae, showing transient dimeric complexes and the role of Rec102 in DNA binding and dimerization.

This study identifies condensin as a regulator of meiotic chromosome axis remodeling near crossover sites in yeast, showing it promotes cohesin removal and affects chromosome segregation.

The paper synthesizes a shorter yeast chromosome and studies its fusion with other chromosomes, revealing new 3D structural interactions and Red1 binding patterns.

The paper analyzes rDNA sequence diversity in Saccharomyces cerevisiae, showing significant variation and purifying selection across rRNA gene copies.

The paper identifies a novel rDNA intermediate formed by topoisomerase I in yeast, which is linked to rDNA stability but independent of Fob1 and S phase.

The paper identifies two pathways for meiotic chromosome axis assembly in yeast, showing cohesin-dependent and cohesin-independent mechanisms recruit axis proteins to genomic regions with high gene density.

This study investigates the roles of topoisomerases I and II in meiotic DNA breakage and chromosome remodeling in yeast, showing distinct effects of their disruption on DSB timing and chromosome structure.

The paper identifies privileged end-adjacent regions near telomeres that maintain DSBs and contribute to higher recombination rates on short chromosomes in yeast.

SNP-ChIP quantifies changes in protein binding across the genome using intra-species SNPs for normalization, improving between-sample comparisons in ChIP-seq.

The paper shows yeast uses extrachromosomal rDNA circles to restore copy number after loss, similar to cancer mechanisms.

This study shows that acute condensin depletion in yeast causes genome decompaction without affecting global gene expression levels.