Author

Elka Kyurkchieva

University of GlasgowORCID 0009-0007-8667-5437Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Jiayue LingiD· 2 shared Alina ZorniD· 1 shared Bria O’Gorman· 1 shared Chih-Jung Chang· 1 shared Connor M. BlairiD· 1 shared Danny T. Huang· 1 shared George S. BaillieiD· 1 shared George S. Baillie· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCell Biology

Jiayue LingORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintAug 11, 2026

Reduced PDE4D expression and activity in Acrodysostosis Type 2 patient fibroblasts underlie disease pathology

Oliver F. W. Gardner, Jiayue Ling, Tawan Munkongcharoen…·Patrizia Ferretti

This study shows reduced PDE4D expression and activity in ACRDYS2 patient fibroblasts, leading to altered cAMP/PKA signaling and compensatory changes in PDE4B.

DOI 10.64898/2026.08.10.743905

humanbulk RNA-seq

Cancer BiologyMolecular Therapy OncologyPeer-reviewedAug 6, 2025

Targeting MDM2 homodimer and heterodimer disruption with DRx-098D in TP53 wild-type and mutant cancer cells

Sean F Cooke, Thomas A. Wright, Gillian Lappin…·Connor M. Blair

This study shows DRx-098D, a peptide disrupting MDM2 dimerisation, effectively inhibits cancer cell growth in TP53 wild-type and mutant cell lines, outperforming Idasanutlin in TP53 null cells.

2 citations

humanexperimental assay