Author

Jiayue Ling

University of GlasgowORCID 0000-0002-4048-5634Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Elka KyurkchievaiD· 2 shared George S. BaillieiD· 2 shared Aleksandra Judina· 1 shared Alina Zorn· 1 shared Alina ZorniD· 1 shared Ao LiiD· 1 shared Bria O’Gorman· 1 shared Cathy Swindlehurst· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

Elka KyurkchievaORCID

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3 papers

Recent·Most cited

Long-PDE4D degradation attenuates left ventricular cardiomyocyte hypertrophic remodelling

Aleksandra Judina, Zhiyao Shi, Jiarong Fu, Ivan Sherstnev, Veronika Boichenko, Jiayue Ling, Madihah Hussain, Alina Zorn, Yuan Yan Sin, Houcheng Wang, Ao Li, Sasha Korogodski, Eduardo Torres, David Stirling, Kyle Chan, , Julia Gorelik

This study shows that targeted degradation of long PDE4D isoforms reduces cardiac hypertrophy without affecting contractile function in rat and human cardiomyocytes.

bioRxiv · Nov 2, 2026 · PreprintPharmacology & Toxicology

Reduced PDE4D expression and activity in Acrodysostosis Type 2 patient fibroblasts underlie disease pathology

Oliver F. W. Gardner, Jiayue Ling, Tawan Munkongcharoen, Elka Kyurkchieva, Harry G. Leitch, Louise C. Wilson, George S. Baillie, Patrizia Ferretti

This study shows reduced PDE4D expression and activity in ACRDYS2 patient fibroblasts, leading to altered cAMP/PKA signaling and compensatory changes in PDE4B.

bioRxiv · Aug 11, 2026 · PreprintCell Biology

Targeting MDM2 homodimer and heterodimer disruption with DRx-098D in TP53 wild-type and mutant cancer cells

Sean F Cooke, Thomas A. Wright, Gillian Lappin, Elka Kyurkchieva, Yuan Yan Sin, Jiayue Ling, Alina Zorn, Bria O’Gorman, William Banyard, Chih-Jung Chang, Helen Wheadon, Danny T. Huang, George S. Baillie, Connor M. Blair

This study shows DRx-098D, a peptide disrupting MDM2 dimerisation, effectively inhibits cancer cell growth in TP53 wild-type and mutant cell lines, outperforming Idasanutlin in TP53 null cells.

Molecular Therapy Oncology · Aug 6, 2025Peer-reviewedCancer Biology