PhysiologybioRxivPreprint
Improvement in Outcomes and Prevention of Multiple Organ Dysfunction Syndrome After Cardiac Arrest and Successful Cardiopulmonary Resuscitation by Systemic Administration of Bumetanide in Male Mice
Zhun Yao, Yuanrui Zhao, Liping Lu…·Zhui Yu
This study shows that systemic bumetanide administration after cardiac arrest and CPR improves survival, reduces brain injury, and prevents multiple organ dysfunction in male mice, with LCN2/NGAL identified as a potential biomarker for early neuroprognostication.
DOI 10.1101/2024.05.08.593259