Synthetic BiologybioRxivPreprint
Generating E. coli 0.5 controlled by a half-sized genome
Takahito Mukai, Aika Ohishi, Emi Hagiuda…·Masayuki Su’etsugu
The paper constructs a half-sized E. coli genome through genome-scale debugging and integrates it into a functional genome, resulting in a smaller genome than previously reported.
DOI 10.64898/2026.06.01.729178