Author

Pierre Brézellec

Centre National de la Recherche ScientifiqueORCID 0009-0008-1531-5714Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 3

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein design· 1

Frequent Co-Authors

Sophie PasekiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

3 papers

Recent·Most cited

GenomicsbioRxivPreprintOct 11, 2026

A Plasmid-Derived Machinery Drives Chromosomal Replication Initiation in the Colorectal Cancer-Associated Bacterium Fusobacterium nucleatum and Its Close Relatives

Sophie Pasek, Pierre Brézellec

The paper shows that Fusobacteriaceae bacteria use a plasmid-derived replication initiator protein, RPA, instead of the chromosomal dnaA gene, displacing the ancestral system.

DOI 10.64898/2026.10.08.757545

bacteria (other)whole-genome sequencing

𝕏 PostBluesky

GenomicsPeer Community JournalPeer-reviewedFeb 17, 2026

In silico evidence suggests that the SARS-CoV-2 Spike protein may target coiled-coil regions of numerous cytoskeletal and cytoskeleton-associated proteins

Pierre Brézellec

The paper analyzes SARS-CoV-2-human protein-protein interactions to show Spike S may target cytoskeletal proteins via coiled-coil domains.

DOI 10.24072/pcjournal.681

humanproteomics

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GenomicsPeer Community JournalPeer-reviewedNov 26, 2024

Re-annotation of SARS-CoV-2 proteins using an HHpred-based approach opens new opportunities for a better understanding of this virus

Pierre Brézellec

This paper re-annotates SARS-CoV-2 proteins using HHpred, identifying new similarities with human proteins that may inform viral function and host interactions.

3 citations

humanprotein sequence

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