Author

Güler Gül

University of EdinburghORCID 0009-0008-5057-4957Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Claire PallesiD· 2 shared Ian P.M. TomlinsoniD· 2 shared James F. WilsoniD· 2 shared Juan J. Fernandez-TajesiD· 2 shared Kitty SherwoodiD· 2 shared S. ThorniD· 2 shared Anders IsakssoniD· 1 shared Anusha AmanullahiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Claire PallesORCID

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2 papers

Recent·Most cited

Genetic & Genomic MedicineGutPeer-reviewedSep 11, 2026

Heterozygous germline MSH3 mutations, and probably MLH3 mutations, act as classical tumour suppressors, leading to excess somatic deletion mutations, signature ID4 and increased colorectal cancer risk

Ignacio Soriano, Kitty Sherwood, Joseph C Ward…·Ian P.M. Tomlinson

DOI 10.1136/gutjnl-2026-338390

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintNov 20, 2025

Germline haploinsufficiency for the base excision repair gene MUTYH causes mutational signature SBS18 in multiple tumour types, specifically leading to an increased risk of colorectal cancer

Kitty Sherwood, Juan J. Fernandez-Tajes, Güler Gül…·Ian P.M. Tomlinson

This study shows that germline MUTYH haploinsufficiency increases mutational signature SBS18 and CRC risk, but not other cancers, due to oxidative DNA damage in the colorectum.

DOI 10.1101/2025.11.20.25340655

humanwhole-genome sequencing

𝕏 PostBluesky