Kitty Sherwood

BatchVaria evaluates batch correction methods by comparing variance changes across configurations using TCGA breast cancer RNA-seq data.

This study identifies DNA methylation differences between microsatellite stable and microsatellite instable colorectal cancers, revealing MLH1-independent markers of mismatch repair deficiency and the impact of anatomical location.

This study shows that germline MUTYH haploinsufficiency increases mutational signature SBS18 and CRC risk, but not other cancers, due to oxidative DNA damage in the colorectum.

The paper identifies two divergent structural variation trajectories in HGSOC that impact patient survival and reveals novel candidate driver genes and mtDNA mutations associated with prognosis.