Jihae Lee

The paper uses an AI-driven framework to model perturbations in brain organoids and identifies candidate genes for autism using genomic and clinical data.

This study develops a method to generate human anterior neural organoids (hANOs) and uses them to model microcephaly in Cohen syndrome by analyzing gene expression and cellular phenotypes.

The paper constructs a single-cell atlas of developing human brains to analyze the temporal and cellular specificity of neurological disorder genes across 393,060 cells.