Eric Nguyen

This paper introduces the EDEN family of foundation models for AI-programmable therapeutic design, demonstrating their ability to generate functional gene insertions, antibiotic peptides, and synthetic microbiomes.

This paper introduces a genomic language model, Evo, capable of generating functional de novo genes through semantic mining, validated by experimental testing of anti-CRISPR proteins and toxin-antitoxin systems.

A 40B-parameter DNA model trained on 9.3 trillion tokens scores coding and noncoding variants zero-shot, exposes interpretable sequence features, and writes chromosome-scale sequences.

7B-parameter convolution-attention DNA model with 131 kb context, trained on prokaryotic genomes, performs zero-shot fitness and essentiality prediction and generates Cas loci, transposons, and 650 kb sequences.