Author

Michael Poli

Stanford UniversityORCID 0000-0001-5384-9372Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:sequence-to-function modeling· 2 Approach:transformer / foundation model· 2 Research Focus:variant effect prediction· 2 Assay:whole-genome sequencing· 2 Organism:bacteria (other)· 1 Approach:benchmark study· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

Brian HieiD· 2 shared Christopher RéiD· 2 shared David B. LiiD· 2 shared Eric NguyeniD· 2 shared Garyk BrixiiD· 2 shared Jeremy Sullivan· 2 shared Madelena Y. NgiD· 2 shared Matthew G. DurrantiD· 2 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Brian HieORCID

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Author profile →

2 papers

Recent·Most cited

Genome modeling and design across all domains of life with Evo 2

Garyk Brixi, Matthew G. Durrant, Jerome Ku, Michael Poli, Greg Brockman, Daniel Chang, Gabriel A. Gonzalez, S. B. King, David B. Li, Aditi T. Merchant, Mohsen Naghipourfar, Eric Nguyen, Chiara Ricci-Tam, David W. Romero, Gwanggyu Sun, , Brian Hie

A 40B-parameter DNA model trained on 9.3 trillion tokens scores coding and noncoding variants zero-shot, exposes interpretable sequence features, and writes chromosome-scale sequences.

bioRxiv · Feb 18, 2025 · PreprintGenomics✦ In-depth digest

Sequence modeling and design from molecular to genome scale with Evo

Eric Nguyen, Michael Poli, Matthew G. Durrant, Brian Kang, Dhruva Katrekar, David B. Li, Liam J. Bartie, Armin W. Thomas, Samuel H. King, Garyk Brixi, Jeremy Sullivan, Madelena Y. Ng, Ashley Adanna Lewis, Aaron Lou, Stefano Ermon, , Brian Hie

7B-parameter convolution-attention DNA model with 131 kb context, trained on prokaryotic genomes, performs zero-shot fitness and essentiality prediction and generates Cas loci, transposons, and 650 kb sequences.

Science · Nov 14, 2024Peer-reviewedSynthetic Biology✦ In-depth digest