Carmen Oroperv

This paper introduces BBQ, a tool that improves rare somatic variant calling by modeling sample-specific error rates using overlapping reads, reducing false positives compared to existing tools.

This paper improves ctDNA detection by combining mutation detection with fragmentomic features, achieving higher AUC scores than mutation burden alone.

The paper introduces ctDNAmer, a reference-free tool for detecting ctDNA from WGS data by analyzing k-mers, showing improved tumor fraction estimation and detection compared to traditional methods.