Author

Yi-Gang Chen

Chinese University of Hong KongORCID 0009-0008-7290-0047Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1 Approach:large language model· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Hsien‐Da HuangiD· 3 shared Yang-Chi-Dung LiniD· 3 shared Hsi‐Yuan HuangiD· 2 shared Liping LI· 2 shared Sheng-Han HuangiD· 2 shared Ting-Xuan LiniD· 2 shared Chenyang Jia· 1 shared Danhong DongiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersSystems Biology

Hsien‐Da HuangORCID

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3 papers

Recent·Most cited

Systems BiologybioRxivPreprintJan 11, 2026

The Red Rice Bran Extract (RRBE) Mitigates Photoaging by Targeting Mitochondrial Oxidative Stress and Regulating Thermal Damage Responses

Ting-Xuan Lin, Yi-Gang Chen, Xin Li…·Hsien‐Da Huang

The paper develops an AI-driven platform to analyze RRBE's photoprotective mechanisms, identifying key bioactive compounds and their targets through computational and experimental validation.

DOI 10.64898/2026.01.08.698301

deep learning

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Systems BiologybioRxivPreprintDec 23, 2025

Modulation of signal response by small RNAs through feed-forward loops

Yang-Chi-Dung Lin, Yi-Gang Chen, Ting-Xuan Lin…·Hsien-Da HUANG

The paper identifies sRNA-mediated feed-forward loops in E. coli that modulate gene regulation through distinct dose-response profiles, showing how sRNAs enhance regulatory diversity and efficiency.

DOI 10.64898/2025.12.22.696124

E. coliDNA methylation

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BioinformaticsBriefings in BioinformaticsPeer-reviewedNov 1, 2025

DeepADR: Multi-modal Prediction of Adverse Drug Reaction Frequency by Integrating Early-Stage Drug Discovery Information via Kolmogorov-Arnold Networks

Jingting Wan, Chenyang Jia, Danhong Dong…·Hsien-Da Huang

DeepADR predicts adverse drug reaction frequency using early-stage data by integrating chemical, biological, and semantic information with a Kolmogorov-Arnold Network.

5 citations

deep learninglarge language model

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