Elliot Layne

AtomWeaver enables non-canonical peptide design by using a geometric prior to generate side-chain atoms without restricting residue identity, achieving high agreement with experimental results.

This paper improves de novo peptide binder design by combining peptide-specific finetuning with a novel decoding order strategy, achieving a 16-30% increase in in silico success rates and doubling top-ranking agonists for OPRM1.