Edward Ma

This study compares kinetic and stoichiometric models of CHO metabolism, finding that kinetic models better predict bioprocess outcomes like cell density and metabolite levels.

This paper develops a multi-objective Bayesian Optimization framework for optimizing bioprocess conditions in CHO cell culture, achieving better performance than traditional methods with fewer experiments.

The paper presents iCHO3K, a comprehensive metabolic model of Chinese Hamster cells, and uses it to analyze metabolic changes in lactate-free cells, identifying structural insights into metabolic rewiring.