Author

Yirui Gao

University of California SystemORCID 0009-0008-8214-9461Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

John P. BartoniD· 2 shared Brian LeeiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

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2 shared papersEvolutionary Biology

John P. BartonORCID

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2 papers

Recent·Most cited

Evolutionary BiologybioRxivPreprintJun 8, 2025

Inferring fitness seascapes from evolutionary histories

Yirui Gao, Brian Lee, John P. Barton

The paper infers time-varying selection pressures from genetic data using a statistical physics approach, applied to study HIV-1 immune escape dynamics.

DOI 10.1101/2025.06.08.658500

humanDNA methylation

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Evolutionary BiologyProceedings of the National Academy of SciencesPeer-reviewedFeb 19, 2025

A binary trait model reveals the fitness effects of HIV-1 escape from T cell responses

Yirui Gao, John P. Barton

The paper develops a binary trait model to separate the fitness effects of HIV-1 immune escape from replication, finding that T cell escape contributes significantly to early fitness gains.

10 citations

humanstatistical model

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