Author

Manolo Mischler

InsermORCID 0009-0008-8607-4807Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Organism:E. coli· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Giancarlo CroceiD· 1 shared Lucile ViguéiD· 1 shared Martin WeigtiD· 1 shared Olivier TenailloniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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1 shared paperGenetics

Giancarlo CroceORCID

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1 paper

Recent·Most cited

GeneticsbioRxivPreprintMar 18, 2026

Linking Codon- and Protein-Level Mutation Scores to Population Genetics Reveals Heterogeneous Selection Efficiency Across Escherichia coli Lineages

Manolo Mischler, Lucile Vigué, Giancarlo Croce…·Olivier Tenaillon

The paper quantifies selection efficiency across Escherichia coli lineages by linking mutation scores to population genetics, showing significant variation in selection intensity between synonymous and non-synonymous mutations and pathogenic populations.

DOI 10.64898/2026.03.16.711857

E. coliwhole-genome sequencing

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