Comparing the evolvability of an ancestrally reconstructed and modern adenylate kinase
MacKenzie Patterson, Hannes Ludewig, Christopher Wilson, Daniel Woldring, Chansik Kim, Aedan Using, Joseph Irvin, Douglas L. Theobald, Dorothee Kern
This study compares the evolvability of an ancestrally reconstructed and modern adenylate kinase, finding that the ancestral enzyme tolerates more mutations and generates more viable variants.
bioRxiv · Feb 2, 2026 · PreprintBiochemistry