MacKenzie Patterson

This study identifies pyroptolysins as bacterial toxins with a gasdermin fold that can induce cell death from inside and outside cells, showing activity on low sterol membranes.

The paper presents the first high-resolution structure of two interacting lanthipeptides and shows how they disrupt cell membranes.

This study compares the evolvability of an ancestrally reconstructed and modern adenylate kinase, finding that the ancestral enzyme tolerates more mutations and generates more viable variants.

The paper solves the crystal structure of caryolan-1-ol synthase with and without a substrate analog, revealing structural changes that suggest a mechanism for anti-Markovnikov cyclization.