Frances Di Clemente

This study examines epigenetic, microbiome, and immune differences in early-onset colorectal cancer (EOCRC) compared to average-onset CRC, finding accelerated epigenetic aging and stronger immune-microbe correlations in EOCRC.

All-FIT estimates tumor purity from high-depth sequencing data by analyzing allele frequencies, outperforming existing methods in simulated and clinical data.