Ahmad A. Tarhini

BCL11B targeting in tumor CD8+ T cells amplifies anti-tumor response by blocking exhaustion while promoting stemness and cytotoxicity

This paper shows that reducing BCL11B in CD8+ T cells enhances anti-tumor response by preventing exhaustion and boosting stemness and cytotoxicity.

Primary tumor microbiomes predict distant metastasis of colorectal cancer

The paper identifies microbiome markers in primary colorectal cancer tumors that predict distant metastasis risk using cohort data and molecular techniques.

Epigenetic Modulation, Intra-tumoral Microbiome and Immunity in Early Onset Colorectal Cancer

This study examines epigenetic, microbiome, and immune differences in early-onset colorectal cancer (EOCRC) compared to average-onset CRC, finding accelerated epigenetic aging and stronger immune-microbe correlations in EOCRC.

Candida albicans infiltrates colon and rectal cancers causing therapeutic resistance and decreased survival

This study identifies Candida albicans colonization in colorectal tumors as a factor linked to reduced survival and impaired radiation response.

Effector T Cells under Hypoxia have an Altered Transcriptome Similar to Tumor-Stressed T Cells Found in Non-Responsive Melanoma Patients

This study shows hypoxia alters T cell transcriptomes in melanoma, correlating with poor clinical outcomes in non-responders to immunotherapy.

Tenascin-C in the early lung cancer tumor microenvironment promotes progression through integrin activation and FAK

This study shows that Tenascin-C promotes early lung cancer progression by activating integrins and FAK in mouse models and human lung adenocarcinomas.

A bioinformatics tool for identifying intratumoral microbes from the ORIEN dataset

The paper introduces MEGA, a tool to identify cancer-associated microbes using RNA-seq data from the ORIEN dataset, leveraging graph attention networks and microbial community information.