Author

Melissa Hopkins

University of WashingtonORCID 0009-0009-2029-7351Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:variant effect prediction· 2 Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Douglas M. FowleriD· 2 shared Lea M. StaritaiD· 2 shared Nahum T. SmithiD· 2 shared Sriram PendyalaiD· 2 shared A.Felicia AdebanjoiD· 1 shared Abby V. McGeeiD· 1 shared Abbye E. McEweniD· 1 shared Alan F. RubiniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersGenomics

Douglas M. FowlerORCID

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2 papers

Recent·Most cited

GenomicsbioRxivPreprintOct 11, 2026

Pathway-scale variant effect mapping reveals the importance of cell context

Jessica J. Simon, Sriram Pendyala, A.Felicia Adebanjo…·Douglas M. Fowler

The paper measures variant effects across the MAPK pathway in human cells, revealing how cell context influences variant function and identifying 14,412 previously unknown dominant negative variants.

DOI 10.64898/2026.10.04.756099

humanwhole-genome sequencing

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintNov 12, 2025

Editing stem cell genomes at scale to measure variant effects in diverse cell and genetic contexts

Shawn Fayer, Riddhiman K. Garge, Melissa Hopkins…·Lea M. Starita

The paper develops iPSC-SGE to assess variant effects in diverse genetic and cell contexts, identifying pathogenic variants and essential disease genes.

4 citations

humanCRISPR screen

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