BioinformaticsbioRxivPreprint
SHARP: Generating Synthesizable Molecules via Fragment-based Hierarchical Action-space Reinforcement Learning for Pareto Optimization
Jeonghyeon Kim, Seongok Ryu, Hahnbeom Park, Chaok Seok
SHARP generates drug-like molecules using reinforcement learning with a fragment-based action space, improving synthesizability and binding affinity over existing methods.