Haziq K. Moinudeen

The paper shows that enzyme specialisation can occur without gene duplication in a model where functional redundancy and structural incompatibility drive catalytic reorganisation.

TCF25 is mostly cytoplasmic with a perinuclear membrane-proximal pool, stabilises GPRASP2 against proteasomal degradation, and its C-terminal residues 604-664 are required for their association.

The paper introduces a geometric framework to analyze protein sequence space coverage and connects it to heuristic discovery times using a stochastic exploration model.