BiophysicsScience AdvancesPeer-reviewed
Atomistic Mechanism of Non-Canonical Voltage Gating in TREK K2P Channels
Ye. K. Aldakul, Marcus Schewe, Carlos Coll-Díez…·Han Sun
This paper reveals the atomistic mechanism of voltage gating in TREK K2P channels through molecular dynamics simulations and electrophysiology, showing how SF conformational flexibility and water influx regulate ion permeation.