Antitoxin-induced auto-phosphorylation neutralizes the nucleotidyltransferase toxin AbiEii from Streptococcus agalactiae to safeguard global translation
Tom J. Arrowsmith, Xibing Xu, Sam C Went, Xue Han, Abbie Kelly, Paul Chansigaud, Zara J Emsley, Jeremy Dubrulle, Peter C. Fineran, Pierre Genevaux, Tim R. Blower
This study identifies antitoxin-induced auto-phosphorylation as the mechanism by which AbiEii toxin is neutralized, reclassifying Abi systems as Type VII toxin-antitoxin systems.
bioRxiv · Jan 20, 2026 · PreprintMolecular Biology