Author

Sam C Went

Durham UniversityORCID 0009-0007-5500-7196Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 3 Approach:experimental assay· 3 Assay:DNA methylation· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Tim R. BloweriD· 3 shared Abbie Kelly· 1 shared Aisling BradyiD· 1 shared Aleksei AgapoviD· 1 shared Andrew NelsoniD· 1 shared Anna OlinaiD· 1 shared Charlotte E. ChongiD· 1 shared Darren SmithiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMolecular Biology

Tim R. BlowerORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintSep 24, 2026

Dual ATPase-activated DNA hemimethylation and cleavage by the MANTIS defence system

Steven J. Shaw, Sam C Went, Aleksei Agapov…·Mark D. Szczelkun

The paper defines the mechanism of the MANTIS defence system in Pseudomonas aeruginosa, showing how dual ATPases couple self-modification to non-self restriction through adenine hemimethylation and cleavage.

DOI 10.64898/2026.09.23.753747

bacteria (other)DNA methylation

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Molecular BiologybioRxivPreprintJan 20, 2026

Antitoxin-induced auto-phosphorylation neutralizes the nucleotidyltransferase toxin AbiEii from Streptococcus agalactiae to safeguard global translation

Tom J. Arrowsmith, Xibing Xu, Sam C Went…·Tim R. Blower

This study identifies antitoxin-induced auto-phosphorylation as the mechanism by which AbiEii toxin is neutralized, reclassifying Abi systems as Type VII toxin-antitoxin systems.

DOI 10.64898/2026.01.19.700257

bacteria (other)experimental assay

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MicrobiologyNature CommunicationsPeer-reviewedAug 22, 2024

Structure and rational engineering of the PglX methyltransferase and specificity factor for BREX phage defence

Sam C Went, David M. Picton, Richard Morgan…·Tim R. Blower

The paper characterizes the BREX system in Salmonella, determines the structure of PglX, and shows how rational engineering expands phage targeting and host motif methylation.

20 citations

bacteria (other)structural biology

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