Nicholas Santolla

Kukulu reconstructs antibody CDR loops using a diffusion model with a structure-aware architecture, improving loop design by integrating sequence-structure constraints.

This paper introduces peleke-1, a suite of protein language models fine-tuned for generating targeted antibody sequences from antigen inputs.

This study uses AI to design novel antibodies against recent H5N1 influenza strains, showing they bind similarly to known therapeutic antibodies.