Timothy J Few-Cooper

The paper introduces IMM-AGE, a metric of immune-aging, and shows it independently predicts cardiovascular disease risk across multiple cohorts.

This study identifies age-related defects in CXCL13+ T follicular helper cells in human tonsil organoids, linking them to reduced antibody responses.

The paper compares immune-aging metrics with DNA methylation clocks, showing integrated models outperform single-clock approaches by capturing complementary aging dimensions.

This study identifies BDNF as a regulator of human B lymphopoiesis using a systems biology approach integrating single-cell transcriptomics and intercellular communication mapping.