Shai S. Shen-Orr

The paper introduces IMM-AGE, a metric of immune-aging, and shows it independently predicts cardiovascular disease risk across multiple cohorts.

This study identifies age-related defects in CXCL13+ T follicular helper cells in human tonsil organoids, linking them to reduced antibody responses.

The paper compares immune-aging metrics with DNA methylation clocks, showing integrated models outperform single-clock approaches by capturing complementary aging dimensions.

This study identifies bacterial exposure as a key driver of immune ageing and shows residual bacterial DNA in immune cells predicts immune age changes.

This study identifies BDNF as a regulator of human B lymphopoiesis using a systems biology approach integrating single-cell transcriptomics and intercellular communication mapping.

This study identifies cytokines that enhance influenza vaccine antibody responses in human organoids and mice, showing their potential as adjuvants to improve vaccine efficacy.

The paper introduces a computational framework to identify predictive drug response axes across diseases using blood data, finding the RAC1-PAK1 axis predicts anti-TNF response in inflammatory bowel disease and rheumatoid arthritis.

The paper introduces TimeAx, an algorithm for analyzing disease progression dynamics using time-series data, identifying key molecular transitions and clinical insights in urothelial bladder cancer.

CytoPro is a deconvolution platform that accurately estimates cell-type composition from bulk gene expression, outperforming existing tools in accuracy and robustness.

devMap enables comparison of cancer-related developmental processes across patients by aligning high-dimensional trajectories to a common backbone, revealing conserved signaling patterns in AML.

The paper identifies a polygenic network governing immune homeostasis using mass-cytometry data from 55 mouse strains, showing 52% of trait genes predict phenotype and revealing multi-cellular regulatory complexity.