Direct RNA nanopore sequencing reveals rapid RNA modification changes following glucose stimulation of human pancreatic beta-cell lines
Logan Mulroney, Henry J. Taylor, Angela Lee, Amy J. Swift, Mihail Zdravkov, Lori L. Bonnycastle, Shelise Y. Brooks, Brian N. Lee, Tomas W. Fitzgerald, Narisu Narisu, Leslie G. Biesecker, Michael R. Erdos, Francesco Nicassio, Ewan Birney, Francis S. Collins, D. Leland Taylor
The paper uses direct RNA nanopore sequencing to identify RNA modification changes in human pancreatic beta-cells after glucose stimulation, finding 1,697 differentially modified sites linked to type 2 diabetes genes.
bioRxiv · Jun 12, 2025 · PreprintGenomics