Author

Angela Lee

National Institutes of HealthORCID 0009-0001-3730-6391Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 3 Organism:human· 3 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Approach:experimental assay· 1

Frequent Co-Authors

Amy J. Swift· 3 shared D. Leland TayloriD· 3 shared Francis S. CollinsiD· 3 shared Henry J. TayloriD· 3 shared Lori L. BonnycastleiD· 3 shared Michael R. ErdosiD· 3 shared Narisu NarisuiD· 3 shared Brian N. LeeiD· 2 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Amy J. Swift

Mutual co-authors in cluster

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3 papers

Recent·Most cited

GenomicsbioRxivPreprintJun 12, 2025

Direct RNA nanopore sequencing reveals rapid RNA modification changes following glucose stimulation of human pancreatic beta-cell lines

Logan Mulroney, Henry J. Taylor, Angela Lee…·D. Leland Taylor

The paper uses direct RNA nanopore sequencing to identify RNA modification changes in human pancreatic beta-cells after glucose stimulation, finding 1,697 differentially modified sites linked to type 2 diabetes genes.

DOI 10.1101/2025.06.12.659352

humanlong-read sequencing

𝕏 PostBluesky

GeneticsDiabetologiaPeer-reviewedJul 5, 2024

Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 hours

Caleb M. Grenko, Henry J. Taylor, Lori L. Bonnycastle…·D. Leland Taylor

This study uses single-cell RNA sequencing to analyze gene expression changes in human pancreatic islets under different glucose conditions over 24 hours, identifying genes and modules associated with time, glucose exposure, and their interaction.

15 citationstop 3%

humanscRNA-seq

𝕏 PostBluesky

GeneticsCell MetabolismPeer-reviewedOct 18, 2023

Functional interrogation of twenty type 2 diabetesassociated genes using isogenic hESC-derived β-like cells

Dongxiang Xue, Narisu Narisu, D. Leland Taylor…·Francis S. Collins

This study functionally interrogates 20 T2D-associated genes using isogenic hESC-derived β-like cells, identifying variants and genes linked to insulin production and lipotoxicity sensitivity.

46 citationstop 1%

humanATAC-seq

𝕏 PostBluesky