Marie Kristin Lebherz

DESwoMAN identifies and characterizes novel open reading frames in transcriptomes and analyzes their mutation patterns across species.

The paper models ORF evolution as a Markov-jump process and shows that de novo ORFs are more likely to shrink than elongate in neutral evolution, supporting the idea that selection retains longer ORFs.

The paper identifies de novo transcripts in Drosophila melanogaster and shows they are associated with transposable elements and enriched transcription factor motifs.

This study identifies proto-genes in Drosophila melanogaster, showing they arise rapidly, are frequently lost, and are driven by transposable elements and ORF formation.