BioinformaticsbioRxivPreprint
sc4D: spatio-temporal single-cell transcriptomics analysis through embedded optimal transport identifies joint glial response to Alzheimer's disease pathology
Ishir Rao, M Kellis, Yosuke Tanigawa
sc4D integrates optimal transport with autoencoder embeddings to analyze spatio-temporal single-cell transcriptomics data, revealing glial responses to Alzheimer's disease pathology and predicting therapeutic interventions.
DOI 10.1101/2025.11.19.689166