Raphäelle Quillet

This study develops a spexin analog, LIT-01-144, that activates GALR2 to provide potent non-opioid antinociception in persistent pain without central nervous system penetration.

The paper re-examines the expression and projection patterns of Tacr1 and Gpr83 in spinal projection neurons, finding greater overlap and VPL connectivity than previously reported.

The paper characterizes somatostatin-expressing neurons in the anterolateral system, showing their axonal projections and suggesting a role in the affective-motivational dimension of pain.

The paper uses single-nucleus RNA sequencing to identify five distinct classes of anterolateral system neurons in the adult mouse spinal cord and their laminar distribution.