Author

James E. Gonzales

National Institutes of HealthORCID 0009-0009-7696-7561Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Organism:virus· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1 Approach:graph neural network· 1 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

Abhishek BastirayiD· 2 shared Wonmuk HwangiD· 2 shared Iktae KimiD· 1 shared Jae-Hyun Cho· 1 shared Jaehyun ChoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 8 mutual co-author links

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2 shared papersBiophysics

Abhishek BastirayORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintOct 1, 2026

Network analysis of correlated conformational dynamics across the evolution of influenza A virus NS1

Abhishek Bastiray, James E. Gonzales, Wonmuk Hwang, Jae-Hyun Cho

The paper analyzes the evolution of correlated conformational dynamics in influenza A virus NS1 proteins, revealing a core-periphery structure that enables evolutionary sequence variation while maintaining structural robustness.

DOI 10.64898/2026.09.29.755463

virusprotein structure

𝕏 PostBluesky

BiophysicsProceedings of the National Academy of SciencesPeer-reviewedFeb 20, 2025

Evolutionary rewiring of the dynamic network underpinning allosteric epistasis in NS1 of influenza A virus

James E. Gonzales, Iktae Kim, Abhishek Bastiray…·Jaehyun Cho

This study analyzes how mutations in the NS1 protein of influenza A virus rewired allosteric and epistatic networks, enhancing its binding affinity to p85β.

4 citations

virusstructural biology

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