Author

Sachin Kumar

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

A Sorana Morrissy· 1 shared Aditya GuptaiD· 1 shared Alexandra Joyner· 1 shared Antony Michealraj· 1 shared Archana Sasi· 1 shared Baibaswata NayakiD· 1 shared Betty Luu· 1 shared Bing CheniD· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperCancer Biology

A Sorana Morrissy

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Author profile →

4 papers

Recent·Most cited

Affinity Maturation and Light-Chain-Mediated Paratope Diversification Anticipate Viral Evolution

John G Dingus, Duck Kyun Yoo, Sachin Kumar, Yajuan Wang, Md. Golam Kibria, Shahab Saghaei, Zahra Allahyari, Jessica W. Chen, Natalie Caputo, Jason Hwang, Bing Chen, Duane R. Wesemann

The paper investigates how antibody affinity maturation and light-chain pairing contribute to neutralizing evolved SARS-CoV-2 variants, identifying mechanisms that enable anticipatory immune breadth.

Cell Reports · Dec 30, 2025Peer-reviewedImmunology

Predictive Modeling of acute Graft-versus-Host-Disease using Machine Learning on Immune Cell and Cytokine Profiles at Engraftment

Mohini Mendiratta, Praful Pandey, Shobhit Pandey, Sandeep Rai, Shuvadeep Ganguly, Archana Sasi, Ritu Gupta, Prabhat Singh Malik, Raja Pramanik, Sachin Kumar, Baibaswata Nayak, Ruquaya Mir, Sameer Bakhshi, Deepam Pushpam, Mukul Aggarwal, , Ranjit Kumar Sahoo

This study uses machine learning to predict acute Graft-versus-Host-Disease (aGvHD) based on immune cell and cytokine profiles at engraftment, finding high accuracy with cytokine and T-cell data.

bioRxiv · Mar 13, 2025 · PreprintImmunology

Activity and state-dependent modulation of salt taste behavior via pharyngeal neurons in Drosophila melanogaster

Shivam Kaushik, Rahul Kumar, Sachin Kumar, Srishti Sanghi, Teiichi Tanimura, Diego E. Rincón-Limas, Pinky Kain

This study investigates how Drosophila modulates high salt intake based on diet and state, showing that pharyngeal LSO neurons and dopamine regulate this behavior.

bioRxiv · Feb 1, 2022 · PreprintNeuroscience

Childhood cerebellar tumors mirror conserved fetal transcriptional programs

Maria C Vladoiu, Ibrahim El-Hamamy, Laura K Donovan, Hamza Farooq, Borja L Holgado, Vijay Ramaswamy, Stephen C Mack, John JY Lee, Sachin Kumar, David Przelicki, Antony Michealraj, Kyle Juraschka, Patryk Skowron, Betty Luu, Hiromichi Suzuki, , Michael D. Taylor

The paper uses single-cell transcriptomics to show childhood cerebellar tumors mirror fetal cerebellar cell lineages, linking tumor subtypes to specific developmental stages.

bioRxiv · Jun 19, 2018 · PreprintCancer Biology