MicrobiologyFEMS Microbiology LettersPeer-reviewed
Conserved ancillary residues situated proximally to the VIM-2 active site affect its metallo β-lactamase activity
Diamond Jain, Tejavath Ajith, Jyoti Kumar Verma…·Anindya Sundar Ghosh
The paper investigates the impact of specific amino acid substitutions near the VIM-2 active site on its metallo β-lactamase activity and stability, finding that N210A and D182A reduce catalytic efficiency and thermal stability.